Υποκλινικός υποθυρεοειδισμός σε υπογόνιμες γυναίκες (Master thesis)
Τζουτζέ Μεμέτ Χασάν, Ζεϊνέπ
Purpose of this study is to review of various investigations aimed at discovering correlations between subclinical hypothyroidism (SCH) and infertility in women. Infertility for a couple is the inability to get pregnant after a year of sexual intercourse without contraceptive precautions. In recent 50 to 60 years have witnessed a significant reduction in human fertility, which affects about 10% of couples. In women with unexplained infertility especially those with luteal phase of the cycle failure, the Subclinical Hypothyroidism (SCH) may be the main causative agent. The subclinical hypothyroidism is a disease of the thyroid gland, which in most cases occurs without symptoms. In disease generating mechanism implicated mainly two factors, prolonged exposure to iodine and anti-thyroid antibodies (Anti TPO). Generally considered to be an early phase of thyroid disease over time for 37% of cases will be transferred to a conventional clinical hypothyroidism. The high levels of thyroid stimulating hormone (TSH) in the SCH affecting many functions of the female reproductive system such as ovulation, leading to failure of fertilization and implantation and also may lead to miscarriages and late complications of pregnancy. This is explained by the interaction of anti-thyroid antibodies with receptors for thyroid hormones in endometrial cells. Also in hypothyroidism, the hypothalamic-pituitary-gonadal can affect the peripheral metabolism of sex steroids, such that decrease fertility and cause menstrual disorders. A reliable method of detecting subclinical hypothyroidism is considered with TRH stimulation test with respect to a single measurement value for TSH in serum. Researchers propose a testing TRH stimulation in women suffering from disorders of ovulation, which have normal levels of TSH key, to enable the thyroxine treatment in cases with abnormal. Levothyroxine is used as a drug of choice in the treatment of subclinical hypothyroidism, whose therapeutic benefits in relation to the treatment of infertility in these patients has proven in many clinical studies. However, studies are still needed in order to fully clarify the role of subclinical hypothyroidism in female Infertility.
|Institution and School/Department of submitter:||Δημοκρίτειο Πανεπιστήμιο Θράκης. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής|
|Subject classification:||Human reproduction|
|Keywords:||Υπογονιμότητα,Υποκλινικός υποθυρεοειδισμός,Θυρεοειδής αδένας,Subclinical hypothyroidism,Infertility,Thyroid gland|
|Appears in Collections:||Π.Μ.Σ. ΑΝΘΡΩΠΙΝΗ ΑΝΑΠΑΡΑΓΩΓΗ|
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|TzoutzeMemetChasanZ_2016.pdf||Μεταπτυχιακή εργασία||573.62 kB||Adobe PDF||View/Open|
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