Απεικονιστικά ευρήματα με SD-OCT σε ασθενείς με υγρή ΗΕΩ που δεν ανταποκρίθηκαν στη θεραπεία με ranibizumab (Lucentis) (Master thesis)
Γουργούλη, Ιωάννα
To study and investigate the initial SD-OCT findings in patients with wet Age-related Macular Degeneration (AMD) who did nοt respond to intravitreal ranibizumab treatment. METHODS. In our retrospective study we included 120 eyes of 100 neovascular AMD patients whose first treatment was intravitreal ranibizumab. Our patients were divided in two groups according to their response to the medication, judged by the visual acuity and the central retinal thickness (CRT). Initially, we created the case group which included patients with worsened visual acuity and increased central retinal thichness (n=40). Then the control group was created which randomly included the double number of patients (n=80) whose visual acuity improved and central retinal thickness reduced. Each patient’s data was reviewed including demographic information, clinical records and the imaging findings from the initial OCT.RESULTS. The initial SD-OCT findings from the patients of both groups were studied. The non-responder group had greater rates of pigment epithilial atrophy and pigment epithilial detachment, subretinal and intraretinal fluid, fibrosis and disturbances in the photoreceptor inner and outer segments; however, the differences are not statistically significant.CONCLUSIONS. Althought most of the neovascular AMD patients respond to the intravitreal ranibizumab treatment, the study of initial characteristics of non-responders is crucial in order to avoid ineffective treatments to the benefit of our patients.
Institution and School/Department of submitter: | Δημοκρίτειο Πανεπιστήμιο Θράκης. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής |
Subject classification: | Optical coherence tomography |
Keywords: | Optical coherence tomography,Aged-related macular regeneration,Ranizumab,Ηλικιακή έκφραση ωχράς κηλίδας,Οπτική τομογραφία συνοχής |
URI: | https://repo.lib.duth.gr/jspui/handle/123456789/11797 http://dx.doi.org/10.26257/heal.duth.10579 |
Appears in Collections: | Π.Μ.Σ. ΙΑΤΡΙΚΗ ΑΠΕΙΚΟΝΙΣΗ ΣΤΗΝ ΟΦΘΑΛΜΟΛΟΓΙΑ |
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GourgouliI_2015.pdf | Μεταπτυχιακή εργασία | 2 MB | Adobe PDF | View/Open |
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https://repo.lib.duth.gr/jspui/handle/123456789/11797
http://dx.doi.org/10.26257/heal.duth.10579
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