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Εκτίμηση της ποιότητας ζωής, ποιότητας ύπνου και κόπωσης ασθενών με σύνδρομο απνοιών στον ύπνο (Master thesis)

Τίγκα, Πασχαλίνα

Background: Obstructive sleep apnea (OSA) is a common disorder, associated with a number of medical and psychological consequences. OSA has been associated with considerable impairment of quality of life (QoL) and quality of sleep as well as fatigue. Aim of the study was to investigate the association between OSA severity, QoL, quality of sleep and fatigue.Methods: Consecutive patients referred for polysomnography because of OSA symptoms (n=376, 74.9% males) were prospectively recruited. They all underwent standard diagnostic procedures and completed WHO-5 questionnaire, Pittsburg Sleep Quality Index (PSQI) and Fatigue Severity Scale (FSS) for the assessment of QoL, quality of sleep and fatigue respectively. Results: According to AHI severity, subjects were divided into controls (17.3%), mild (20.5%), moderate (18.9%), and severe OSA (43.2%). The majority of patients (65.7%) had PSQI score>5 indicative of poor sleep quality, while WHO-5 and FSS scores were abnormal in 46.5% and 45.8% respectively. Logistic regression analysis revealed an inverse correlation between average SpO2 during sleep and FSS score (OR 0.852, 95% CI 0.762-0.952, p=0.005) and PSQI score (OR 0.870, 95% CI 0.759-0.997, p=0.045). Conclusions: OSA can cause significant impairment in sleep quality and quality of life, which is associated with nocturnal hypoxia. Fatigue is also present in OSA patients.