Repository of DUTH

Σακχαρώδης Διαβήτης Τύπου ΙΙ και σύγχρονη θεραπευτική (Bachelor thesis)

Παπαδόπουλος, Κωνσταντίνος

Introduction: Diabetes mellitus is a metabolic disorder characterized primarily by chronic hyperglycemia. It may be caused due to impaired insulin secretion, defective action or even coexistence of these two. There are altogether eight different classes of antidiabetes for type 2 diabetes, which are taken orally. These are biguanides, sulfonylureas, thiazolidinediones, meglitinides, glucosidase alpha inhibitors, dipeptidyl peptidase-4 inhibitors, GLP-1 receptor agonists and SGLT2 inhibitors. Aim of study: We studied the use of antidiabetic drugs, in the wider area of Evros - Alexandroupolis, and the way it differentiated according to the demographic characteristics of the sample but also other factors such as the use of new or old generation antidiabetic drugs. At the same time, the probable correlation of type 2 diabetes with demographics and various other health conditions was investigated. Methodology: This pharmaco-epidemiological study included the recording of e- prescribing data from pharmacies in Alexandroupolis for the period between November 1, 2011 and December 31, 2017, as well as their treatment with SPSS Statistics 15. 616 subjects 18 -103 with the sole criterion of consuming at least one antidiabetic drug for type 2 diabetes. Results: The incidence of type 2 diabetes in the total of 616 subjects was 45% in men and 55% in females. Moreover, the incidence of diabetes in subjects under the age of 65 was 34%, and in those over 65 was 66%. The most common antidiabetic drug was metformin with 31.8% of the total, followed by glimepiride with 23.7%, while metformin and other antidiabetic agents were at 18.8% . In addition, it was observed that patients who have never changed their antidiabetic treatment are the majority with 83.6%, while 4.9% of the total has changed from new-generation antidiabetic medicine to old-generation. As for the incidence of diabetes with co-administration with other drugs, the frequencies are as follows: 77.1% for cardiovascular diseases, 56% for hypercholesterolemia and 42.4% for thrombosis. Furthermore, women consumed a CNS drug in a significantly higher percentage of 40.5%, compared with males 23.2%. In conclusion, as far as the multi-drug use of the patients is concerned, 62.2% of the patients consumed more than 7 active substances, 27.4% consumed from 4-6 substances and 10.3% consumed from 1-3.