Clostridioides difficile (Master thesis)

Τσανκώφ, Αλεξάνδρα/ Tsankof, Alexandra

Τhe emergence of multiple clusters of lower respiratory infections in provinces of China in late 2019 resulted in the identification of the SARS-CoV-2 ((+) ssRNA virus, Family: Coronaviridae) as a pathogen of COVID-19 disease and within a few months the development of them in a global pandemic. In turn, the spread of the virus has led to an increase in hospital admissions that required high levels of oxygen therapy, multi-day hospitalization, the use of individual protection measures, and the inclusion of corticosteroids, antiviral therapies, and in many cases broad-spectrum antimicrobials for patient. Bacterial infections have been observed in several respiratory infections, from opportunistic pathogens of the upper respiratory flora to superinfectious pathogens such as Clostridioides difficile, especially in hospital conditions. Clostridioides difficile (Cl.difficile) is an anaerobic Gram (+) sporogenic microbe that can cause a variety of clinical manifestations from mild acute diarrheal syndrome to severe life-threatening colitis. It is the leading cause of Healthcare-Associated Diarrhea with approximately 190,000 infections (Hospital-Onset CDI, HO-CDI) per year and 7,400 deaths in Europe.The host's susceptibility to CDI (Clostridioides difficile Infection) is enhanced by changes in the intestinal microbiome due to exposure of the normal gut flora to antibiotics, by recent hospitalization, advanced age and multiple comorbidities. In conclusion and based on the international literature that is constantly updated and enriched, the infection with Cl.difficile in the context of hospitalization due to COVID-19 has inevitably started to concern the medical community. This dissertation is a retrospective cohort study that examines patients treated for COVID-19 with Clostridioides difficile co-infection, for the time period of May 2021 to May 2022 in the 1st ’Propedeutical Internal Medicine Ward of University Hospital “AHEPA” in Thessaloniki, Greece.
Alternative title / Subtitle: συχνότητα και χαρακτηριστικά της λοίμωξης σε ασθενείς που νοσηλεύθηκαν σε τριτοβάθμιο νοσοκομείο
frequency and characteristics of infection in patients hospitalized in a tertiary hospital in Greece
Institution and School/Department of submitter: Δημοκρίτειο Πανεπιστήμιο Θράκης. Σχολή Επιστημών Υγείας. Τμήμα Μοριακής Βιολογίας και Γενετικής
Subject classification: Coronavirus infections  
Keywords: Clostridioides difficile,SARS-Cov-2,co-infection,Συστάδες,Κορονοϊός,Συλλοίμωξη

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