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Φαρμακοεπιδημιολογική μελέτη ψυχοτρόπων φαρμάκων (Master thesis)

Παναγιώτογλου, Γεώργιος

Introduction: Psychotropics are largely consumed and determine the clinical state of psychiatric patients Object: This pharmacoepidemiological study aimed the investigation of demographics and individual traits of psychotropics users (diagnoses, smoking behavior, B.M.I., clinical state, comorbidities, type of psychotropic, drug co-administration) and searched for correlations between the formentioned factors. Method: A non-interventional retrospective cohort study was conducted among 94 long-stay patients in a Psychiatric Hospital of North Greece between 01/06/2016 and 31/05/2019. All patients went through assessment of their clinical, neurocognitive and functioning state with MMSE and PANSS. The rest of the data (medical history, demographics, drug administration) was collected from hospital’s management software. Ethics approval for the study was given by the Ethics and Deontology Committee of Democritus University of Thrace. Results: Data analysis indicated the predominant use of antipsychotics and anxiolytics among psychotropics and the high prevalence of polypharmacy and comorbidities. Antipsychotics along with benzodiazepines were the most frequent combined psychotropics. In terms of antipsychotic utilization, the combination of classical and atypical was most prevalent and associated with age. Individuals’ MMSE scores were associated with sex, age, smocking behavior and antipsychotics combination, while PANSS positive scale score was determined only by age and smocking. Smocking behavior was most prevalent in male participants and younger ages, while Β.Μ.Ι. showed no correlation with smocking and MMSE/PANSS scores.Conclusion: Individuals’ characteristics and traits are related with MMSE score, as well with the number and type of psychotropics prescribed. In the case of positive PANSS scale, a correlation with patient’s traits is observed and therefore further research is needed.