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Μελέτη της ποιότητας ύπνου και της ποιότητας ζωής ασθενών με σύνδρομο παχυσαρκίας- υποαερισμού (Master thesis)

Λαζαρίδου, Αθηνά

Objectives/Introduction: Obesity is associated with impaired quality of life and sleep. Few studies have investigated the quality of life and sleep quality in patients with obesityhypoventilation syndrome (OHS). The purpose of this study is to investigate the quality of life and sleep in patients with OHS. Methods: The study performed was retrospective. Consecutive subjects who visited the Sleep Unit of the University General Hospital of Alexandroupolis with clinical suspicion of sleep breathing disorder were included in the study. Patients were classified into 3 groups: 1) Group A: Participants with a body mass index (BMI)<30 kg/m2, 2) Group B: Participants with a BMI of 30 kg/m2 without OHS, and 3) Group C: Participants with a BMI ≥ 30 kg/m2 with OHS. To evaluate the quality of life, the Greek version of the WHO-5 questionnaire was used, and to evaluate the quality of sleep, the Greek version of the Pittsburgh Sleep Quality Index (PSQI) questionnaire was used. Then a comparison of the scores of these questionnaires was made between the 3 groups as well as a correlation of the scores of these questionnaires in group C (OHS) with the individual characteristics of the patients. Results: A total of 2639 participants, 1970 males and 669 females, with a mean age of 53.88±12.76 years, of whom 203 suffered from OHS, were included in the study. A statistically significant negative correlation was found between WHO-5 score and neck circumference (r=-0.740, p=0.004) and between WHO-5 score and waist circumference (r=-0.710, p=0.006 in patients with OHS. In addition, a statistically significant positive correlation was also found between the PSQI score and BMI (r=0.420, p=0.026) in these patients. Moreover, a statistically significant lower WHO-5 score was observed in patients with OHS suffering from diabetes mellitus compared to non-diabetics (p=0.015). Conclusions: According to the results of the present study in patients with OHS, greater neck circumference and greater waist circumference are associated with worse quality of life, and a greater BMI is associated with worse sleep quality. Also, patients with OHS and diabetes mellitus have a worse quality of life compared to patients with OHS without diabetes mellitus. Also, there was no statistically significant difference between the quality of life and quality of sleep of obese people with and without OHS although there was statistically significant difference in the ESS Questionnaire between them.