Characteristics of COPD patients under home non-invasive mechanical ventilation (Master thesis)

Καραχρήστος, Χρήστος/ Karachristos, Christos

Background: Sleep disturbances are common in patients with Chronic Obstructive Pulmonary Disease (COPD). The respiratory disturbances that occur in these patients during sleep are oxygen desaturation and development of hypoventilation. Chronic Noninvasive Positive-Pressure Ventilation (NPPV) at home in COPD patients, improves daytime hypercapnia. In our country, NPPV at home is used for several years, in patients with COPD. Nevertheless, there are not overall data to show the impact at the lung function. The Hellenic Registry Home Mechanical Ventilation (HR_HMV) is a national registry of patients with NPPV at home. Methods: Purpose of this retrospective study is the evaluation of the impact at lung function in patients with COPD and chronic NPPV at home, focusing on recording data for adult patients in the HR_HMV registry from 2010. Clinical characteristics, comorbidities, NPPV settings and lung function were evaluated at the initiation of the NPPV and after 6months to 1 year of use. Results: Patients included at the study were > 65 years, obese (BMI>32 kg/m2) and with lots of comorbidities. Assessment of lung function revealed that patients were exhibited with severe COPD (FEV1%=42%), hypoxemia and hypercapnia. Chronic NPPV at home for 6 months to 1 year at those patients, improved blood gases, reduced levels of PaCO2 and HCO3. There were no significant effects at airflow obstruction as shown by spirometry. Conclusion: In patients with severe COPD and hypercapnia the use of chronic NPPV at home for 6 months to 1 year improves blood gases and can stabilize the lung function.
Institution and School/Department of submitter: Δημοκρίτειο Πανεπιστήμιο Θράκης. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Subject classification: Lungs-- Diseases, Obstructive
Keywords: Chronic obstructive pulmonary disease,Non invasive mechanical ventilation,Pulmonary disease,Χρόνια αποφρακτική πνευμονοπάθεια,Μη επεμβατικός μηχανικός αερισμός,Πνευμονοπάθεια
URI: https://repo.lib.duth.gr/jspui/handle/123456789/17807
http://dx.doi.org/10.26257/heal.duth.16541
Appears in Collections:Π.Μ.Σ. ΙΑΤΡΙΚΗ ΤΟΥ ΥΠΝΟΥ

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https://repo.lib.duth.gr/jspui/handle/123456789/17807
http://dx.doi.org/10.26257/heal.duth.16541
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