Impulse oscillometry measurements in patients with obstructive sleep apnea sendrome (Master thesis)
Καλτσάς, Κωνσταντίνος/ Kaltsas, Konstantinos
Background: Obstructive Sleep Apnea is caused by partial or complete obstruction of the upper airway during sleep. However, peripheral airways are also possibly involved in the pathogenesis of the syndrome. Impulse oscillometry is a non-invasive diagnostic tool that implements sound waves to evaluate respiratory mechanics and requires minimal cooperation. Objective: The aim of this study was to perform impulse oscillometry on both patients with OSAS and healthy controls in seated and supine position, in order to detect differences between the two
groups, changes between the two positions, as well as possible correlations between the measurements, their changes due to posture and the polysomnographic parameters. Methods: 16 patients with recently diagnosed OSAS were included in the study and subjected to
impulse oscillometry in both seated and supine position. The control group comprised of 7 healthy individuals who underwent the same diagnostic procedures. We compared the results between the
two groups and the changes in the two positions and assessed the correlations between the oscillometric measurements and the polysomnographic parameters. Results: The two groups differed in the BMI (35.57±6.36 patients vs 27.02±2.77 controls, p=0.001), whereas no statistically significant difference was found regarding age (p=0.639) and height (p=0.159). In the seated position, all oscillometric values (Z5, R5, R20, R5-R 20, Χ5., ΑΧ and fres) were significantly higher in OSAS patients compared to controls, while in the supine position all
values, except for R5-R20 and fres, were higher in the OSAS group. When changing from seated to supine position, Z5, R5 and R20 increased significantly in OSAS patients, while in controls a statistically significant increase was noted in Z5, R5, R20, R5-R20 and fres. When comparing the changes due to posture between the two groups, a significantly higher increase in fres, both as an absolute value (Δfres) (p=0.033) and in percentage (Δfres%) (p=0,016) was observed in the control group. In the OSAS group, a positive correlation was determined between Δfres and supine AHI (r=0.55, p=0.027), as well as between Δfres% and supine AHI (r=0.053, p=0.026). In addition,
supine R5-R20 was negatively correlated with AI (r=-0.052, p=0.027) and supine X5 was negatively correlated with HI (r=-0.54, p=0.031).
Conclusions: Impedance, resistance and absolute reactance values are higher in patients with OSAS suggesting both upper airway disease, as well as involvement of the lung periphery. Impulse oscillometry indices can be useful for the evaluation of OSAS severity.
Institution and School/Department of submitter: | Δημοκρίτειο Πανεπιστήμιο Θράκης. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής |
Subject classification: | Sleep apnea sendromes |
Keywords: | Obstructive sleep apnea sendrome,Impulse oscillometry,Sleep,Σύνδρομο αποφρακτικών απνοιών στον ύπνο,Παλμική ταλαντωσιμετρία,Ύπνος |
URI: | https://repo.lib.duth.gr/jspui/handle/123456789/17808 http://dx.doi.org/10.26257/heal.duth.16542 |
Appears in Collections: | Π.Μ.Σ. ΙΑΤΡΙΚΗ ΤΟΥ ΥΠΝΟΥ |
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KaltsasK_2023.pdf | Μεταπτυχιακή εργασία | 717.38 kB | Adobe PDF | View/Open Request a copy |
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https://repo.lib.duth.gr/jspui/handle/123456789/17808
http://dx.doi.org/10.26257/heal.duth.16542
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