Evaluation of factors influencing the administered therapeutic CPAP pressure, in patients with severe obstructive sleep apnea syndrome (Master thesis)
Μάνιου, Χρυσούλα/ Maniou, Chrysoula
Objectives/Introduction: Obstructive sleep apnea syndrome (OSAS) is the most common sleep-related breathing disorder caused by repeated upper airway obstruction during sleep, and continuous positive airway pressure (CPAP) is the treatment of choice. The aim of this study was to evaluate the factors influencing the administered therapeutic CPAP pressure in patients with severe OSAS. Methods: The study retrospectively included adult patients who visited the sleep study unit of the Sismanoglio Hospital, with clinical suspicion of sleep breathing disorder in the period 2006-2022. Information regarding neck circumference (NC), body mass index (BMI), age, apnea-hypopnea index (AHI) were filled in, for each patient. The value of 3 equations (E1, E2 and E3) that have been used in the literature to predict the optimal CPAP pressure were also calculated: E1: (0.16 × BMI) + (0.13 × NC) + (0.04 × AHI)−5.12, E2: (0.193 × BMI) + (0.077 × NC) + (0.02 × AHI)−0.611
E3: (0.13 × BMI) + (0.16 × NC) + (0.04 × AHI)−5.12.
NC, BMI, AHI, and E1, E2, and E3 values were then correlated with optimal CPAP pressure. Results: A total of 500 participants were included in the study, 414 men and 86 women, with a mean age of 55.49±12.24 years. According to the regression analysis, there was a statistically significant but low correlation between BMI, neck circumference and AHI and optimal CPAP pressure. A statistically significant but moderate correlation of the value of E1, E2 and E3 with the optimal CPAP pressure was also observed. Patients were further divided into patients with optimal CPAP pressure >8 cm H2O and patients with optimal CPAP pressure <8 cm H2O. It was observed that BMI, neck circumference, AHI, E1, E2 and E3 parameters were independently associated with optimal CPAP>8 cm H2O. The greatest ability to predict optimal CPAP>8 cmH20 was presented by the E3 value (area under the curve, AUC 0.733) with an E3 value>7.198 predicting with 74.9% sensitivity and 62.3% specificity an optimal CPAP pressure>8 cmH2O. Conclusions: Neck circumference, BMI and AHI as well as equations including these parameters show low to moderate correlation with optimal CPAP pressure with the E3 value demons-trating the greatest ability to predict optimal CPAP>8 cmH20, in patients with severe OSAS.
Institution and School/Department of submitter: | Δημοκρίτειο Πανεπιστήμιο Θράκης. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής |
Subject classification: | Sleep apnea syndromes |
Keywords: | Sleep apnea,Optimal CPAP pressure,Factors evaluation,Υπνική άπνοια,Θεραπευτική πίεση CPAP,Εκτίμηση παραγόντων |
URI: | https://repo.lib.duth.gr/jspui/handle/123456789/18157 http://dx.doi.org/10.26257/heal.duth.16890 |
Appears in Collections: | Π.Μ.Σ. ΙΑΤΡΙΚΗ ΤΟΥ ΥΠΝΟΥ |
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ManiouCh_2024.pdf | Μεταπτυχιακή εργασία | 848.99 kB | Adobe PDF | View/Open Request a copy |
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https://repo.lib.duth.gr/jspui/handle/123456789/18157
http://dx.doi.org/10.26257/heal.duth.16890
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