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25 - υδροξυβιταμίνης d (25-ΟΗ-D) στον ορό ασθενών με αυτοάνοσο θυρεοειδίτιδα με την ραδιοανοσολογική μέθοδο RIA και συσχέτιση με τον σπινθηρογραφικό έλεγχο θυρεοειδούς (Bachelor thesis)

Κρασά, Φλωρεντία

Vitamin D is an organic substance with a dual role. It has the ability to function both as a hormone and as a vitamin. It is mainly produced in the skin and regulates the expression of a large number of genes. Vitamin D receptor (VDR) is found in most cells and most tissues in the body. The main role of vitamin D is to regulate bone metabolism but also to maintain the homeostasis of calcium and phosphorus. Recent studies have shown that low levels of Vitamin D have been linked to autoimmune thyroid disease (AITD). AIM: The aim of this study is to evaluate the 25-Hydroxyvitamin D serum levels in patients with autoimmune thyroiditis, in relation to thyroid scintigraphy. PATIENT AND METHODS: We studied 30 patients (21 females and 9 males) aged between 36 and 46 years (median age 41 ± 5 years) who suffered from autoimmune diseases. All were followed up at the University Hospital of Evros and from external Endocrinologists who were referred to the University Laboratory of Nuclear Medicine Dept. of the University Hospital of Evros, Democritus University of Thrace. All patients underwent thyroid gland scintigraphy with Tc99-NAOH in the in vivo unit of the laboratory and at the same time blood sample was taken to determine thyroid hormones (T3-FT4-TSH), specific Anti-Tg and Anti-TPO antibodies and 25-OH-D. The hormones levels were measured by radioimmunoassay (RIA) method with Diasorin kit (for TSH), Izotop kit (for Anti-Tg and Anti-TPO) and Beckman Coulter (for 25-OH-D). Statistical analysis was performed by the x2-test and statistical significance was considered for p< 0,005 RESULTS: The majority of patients with thyroiditis had elevated levels of serum Anti-Tg and Anti-TPO antibodies while having low Vitamin D serum levels (p<0,005). CONCLUSIONS: Measuring Vitamin D values along with antibodies is useful in monitoring patients with autoimmune thyroiditis, as well as for assessing the severity of the disease.