Study of sleep disorders in patients with cystic fibrosis (Master thesis)
Παπαδάκη, Ελένη/ Papadaki, Eleni
Introduction: Cystic Fibrosis (CF) is the most common inherited disease among the Caucasian race. Although the main manifestations of CF involve the respiratory and gastrointestinal system, CF affects nearly the total of the systems of the human body. Recently, research has been focused on sleep disorders among patients with CF, which appear to be an important comorbidity that is frequently underdiagnosed.
Aim: The aim of this study is to evaluate sleep disorders in adult, stable patients with CF and to correlate these disorders with their lung function, as well as other clinical parameters. Patients and Methods: Stable adult patients with CF who are systematically examined in the Adult Cystic Fibrosis Centre of the Respiratory Department of AUTH were included. The participants underwent pulmonary lung function testing, evaluation of their vital signs and 6 minute walking test. Also, they were asked to answer the following sleep related questionnaires: Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and Athens Insomnia Scale (AIS). They also answered the mMRC questionnaire, in order to evaluate their dyspnea. The Kerem questionnaire was also completed evaluating the quantity of cough during the day and the night. Results: 18 adult patients with CF (13 men and 5 women) in a stable condition were included in this study. Their mean age was 30.17 (± 7.21) years and their mean value of BMI was 21.36 (± 2.95) kg/m2. As far as their respiratory function is concerned, the mean value of % predicted FEV1 and FVC was 58.93 (± 25.07) and 75.37 (± 26.14) respectively. The average score of ESS was 6.61 (± 3.05), of PSQI 5.06 (± 4.15) and of AIS 4.39 (± 4.67). There was a strong and statistically important negative correlation between SpO2% and PSQI score (p=0.03). Furthermore, there was a statistically important positive correlation between nocturnal cough and AIS (p=0.008) and PSQI score (p=0.001). Finally, the score in the Kerem nighttime questionnaire differed in a statistically important way, depending on chronic infection with P.aeruginosa. Conclusion: Sleep disorders are common among patients with CF and could negatively affect the quality of life of CF patients. Therefore, quality of sleep should be systematically evaluated. Lung function and nocturnal cough seem to correlate with sleep quality of the patients.
Institution and School/Department of submitter: | Δημοκρίτειο Πανεπιστήμιο Θράκης. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής |
Subject classification: | Sleep disorders |
Keywords: | Sleep disorders,Cystic fibrosis,Sleep quality questionaries,Διαταραχές ύπνου,Κυστική ίνωση,Ερωτηματολόγιο ποιότητας ύπνου |
URI: | https://repo.lib.duth.gr/jspui/handle/123456789/19107 http://dx.doi.org/10.26257/heal.duth.17831 |
Appears in Collections: | Π.Μ.Σ. ΙΑΤΡΙΚΗ ΤΟΥ ΥΠΝΟΥ |
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PapadakiE_2023.pdf | Μεταπτυχιακή εργασία | 1.54 MB | Adobe PDF | View/Open Request a copy |
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https://repo.lib.duth.gr/jspui/handle/123456789/19107
http://dx.doi.org/10.26257/heal.duth.17831
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